Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity
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چکیده
منابع مشابه
Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines
Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...
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BACKGROUND We explored the concept of heterologous prime/boost vaccination using 2 therapeutic vaccines currently in clinical development aimed at treating chronically infected hepatitis C virus (HCV) patients: prime with a DNA-based vaccine expressing HCV genotype 1a NS3/4A proteins (ChronVac-C) and boost with a modified vaccinia virus Ankara vaccine expressing genotype 1b NS3/4/5B proteins (M...
متن کاملGlycosylation on the Immunogenicity of DNA Vaccines
131 Received September 22, 2014; revised and accepted May 21, 2015. Published online June 9, 2015; doi: 10.1620/tjem.236.131. Correspondence: Yiping Xing, M.D., Ph.D., Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu, China. e-mail: [email protected] N-Linked Glycosylation at an Appropriate Position ...
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Among the emerging subunit vaccines are recombinant protein- and synthetic peptide-based vaccine formulations. However, proteins and peptides have a low intrinsic immunogenicity. A common strategy to overcome this is to co-deliver (an) antigen(s) with (an) immune modulator(s) by co-encapsulating them in a particulate delivery system, such as poly(lactic-co-glycolic acid) (PLGA) particles. Parti...
متن کاملDistribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice.
Intramuscular injection of DNA vaccines elicits potent humoral and cellular immune responses in mice. However, DNA vaccines are less efficient in larger animal models and humans. To gain a better understanding of the factors limiting the efficacy of DNA vaccines, we used fluorescence-labeled plasmid DNA in mice to 1) define the macroscopic and microscopic distribution of DNA after injection int...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2021
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.202152447